منابع مشابه
Sp8 regulates inner ear development.
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and ...
متن کاملThe development of the vertebrate inner ear
The inner ear is a complex sensory organ responsible for balance and sound detection in vertebrates. It originates from a transient embryonic structure, the otic vesicle, that contains all of the information to develop autonomously into the mature inner ear. We review here the development of the otic vesicle, bringing together classical embryological experiments and recent genetic and molecular...
متن کاملMolecular mechanisms of inner ear development.
The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Henc...
متن کاملAutoimmune Inner Ear Disease- A Clinical Viewpoint
Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...
متن کامل09-P050 SoxE genes in mouse inner ear development
ware employs image filtering and mathematical morphology techniques. It counts cell number from a confocal stack of images, by analysing cells in 2D and 3D throughout the whole stack. Quantification is automatic, accurate, objective and very fast, enabling reliable comparisons of multiple specimens of diverse genotypes. Although DeadEasy was developed and validated for Drosophila, it can be use...
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ژورنال
عنوان ژورنال: Journal of Anatomy
سال: 2016
ISSN: 0021-8782
DOI: 10.1111/joa.12548